Peer Reviewed

Mukherjee A, Halassa MM. The Associative Thalamus: A Switchboard for Cortical Operations and a Promising Target for Schizophrenia. Neuroscientist. 2024 Feb;30(1):132-147. doi: 10.1177/10738584221112861. Epub 2022 Aug 8.PMID: 38279699 Review.

Wang BA, Drammis S, Hummos A, Halassa MM, Pleger B. Modulation of prefrontal couplings by prior belief-related responses in ventromedial prefrontal cortex. Front Neurosci. 2023 Nov 15;17:1278096. doi: 10.3389/fnins.2023.1278096. eCollection 2023.PMID: 38033544

Hummos A, Wang BA, Drammis S, Halassa MM, Pleger B.Thalamic regulation of frontal interactions in human cognitive flexibility. PLoS Comput Biol. 2022 Sep 12;18(9):e1010500. doi: 10.1371/journal.pcbi.1010500. eCollection 2022 Sep.PMID: 36094955

Wang MB, Halassa MM. Thalamocortical contribution to flexible learning in neural systems. Netw Neurosci. 2022 Oct 1;6(4):980-997. doi: 10.1162/netn_a_00235. eCollection 2022.PMID: 36875011.

Mukherjee A, Lam NH, Wimmer RD, Halassa MM. Thalamic circuits for independent control of prefrontal signal and noise. Nature. 2021 Oct. doi: 10.1038/s41586-021-04056-3.

Halassa MM. Genetic variability of memory performance is explained by differences in the brain’s thalamus. Nature. 2020 Nov;587(7835):549-550. doi: 10.1038/d41586-020-03195-3. PMID: 33199900.

Mukherjee A, Bajwa N, Lam NH, Porrero C, Clasca F, Halassa MM. Variation of connectivity across exemplar sensory and associative thalamocortical loops in the mouse. Elife. 2020 Oct 26;9:e62554. doi: 10.7554/eLife.62554. PMID: 33103997; PMCID: PMC7644223.

Li Y, Lopez-Huerta VG, Adiconis X, Levandowski K, Choi S, Simmons SK, Arias-Garcia MA, Guo B, Yao AY, Blosser TR, Wimmer RD, Aida T, Atamian A, Naik T, Sun X, Bi D, Malhotra D, Hession CC, Shema R, Gomes M, Li T, Hwang E, Krol A, Kowalczyk M, Peça J, Pan G, Halassa MM, Levin JZ, Fu Z, Feng G. Distinct subnetworks of the thalamic reticular nucleus. Nature. 2020 Jul;583(7818):819-824. doi: 10.1038/s41586-020-2504-5. Epub 2020 Jul 22. PMID: 32699411; PMCID: PMC7394718.

Gong X, Mendoza-Halliday D, Ting JT, Kaiser T, Sun X, Bastos AM, Wimmer RD, Guo B, Chen Q, Zhou Y, Pruner M, Wu CW, Park D, Deisseroth K, Barak B, Boyden ES, Miller EK, Halassa MM, Fu Z, Bi G, Desimone R, Feng G. An Ultra-Sensitive Step-Function Opsin for Minimally Invasive Optogenetic Stimulation in Mice and Macaques. Neuron. 2020 Jul 8;107(1):197. doi: 10.1016/j.neuron.2020.06.018. Erratum for: Neuron. 2020 Apr 29;: PMID: 32645306; PMCID: PMC7401486.

Gong X, Mendoza-Halliday D, Ting JT, Kaiser T, Sun X, Bastos AM, Wimmer RD, Guo B, Chen Q, Zhou Y, Pruner M, Wu CW, Park D, Deisseroth K, Barak B, Boyden ES, Miller EK, Halassa MM, Fu Z, Bi G, Desimone R, Feng G. An Ultra-Sensitive Step-Function Opsin for Minimally Invasive Optogenetic Stimulation in Mice and Macaques. Neuron. 2020 Jul 8;107(1):38-51.e8. doi: 10.1016/j.neuron.2020.03.032. Epub 2020 Apr 29. Erratum in: Neuron. 2020 Jul 8;107(1):197. PMID: 32353253; PMCID: PMC7351618.

Reed MD, Yim YS, Wimmer RD, Kim H, Ryu C, Welch GM, Andina M, King HO, Waisman A, Halassa MM, Huh JR, Choi GB. IL-17a promotes sociability in mouse models of neurodevelopmental disorders. Nature. 2020 Jan;577(7789):249-253. doi: 10.1038/s41586-019-1843-6. Epub 2019 Dec 18. PMID: 31853066.

Nakajima M, Schmitt LI, Feng G, Halassa MM. Combinatorial Targeting of Distributed Forebrain Networks Reverses Noise Hypersensitivity in a Model of Autism Spectrum Disorder. Neuron. 2019 Nov 6;104(3):488-500.e11. doi: 10.1016/j.neuron.2019.09.040. Epub 2019 Oct 21. PMID: 31648899; PMCID: PMC7278896.

Halassa MM, Sherman SM. Thalamocortical Circuit Motifs: A General Framework. Neuron. 2019 Sep 4;103(5):762-770. doi: 10.1016/j.neuron.2019.06.005. PMID: 31487527; PMCID: PMC6886702.

Parr T, Rikhye RV, Halassa MM, Friston KJ. Prefrontal Computation as Active Inference. Cereb Cortex. 2020 Mar 21;30(2):682-695. doi: 10.1093/cercor/bhz118. PMID: 31298270; PMCID: PMC7444741.

Nakajima M, Schmitt LI, Halassa MM. Prefrontal Cortex Regulates Sensory Filtering through a Basal Ganglia-to-Thalamus Pathway. Neuron. 2019 Aug 7;103(3):445-458.e10. doi: 10.1016/j.neuron.2019.05.026. Epub 2019 Jun 12. PMID: 31202541; PMCID: PMC6886709.

Zhou T, Halassa MM. LC modulation of sensory feature selectivity. Nat Neurosci. 2019 Jan;22(1):5-6. doi: 10.1038/s41593-018-0302-2. PMID: 30559473.

Rikhye RV, Gilra A, Halassa MM. Thalamic regulation of switching between cortical representations enables cognitive flexibility. Nat Neurosci. 2018 Dec;21(12):1753-1763. doi: 10.1038/s41593-018-0269-z. Epub 2018 Nov 19. PMID: 30455456; PMCID: PMC7225728.

Mihali A, Young AG, Adler LA, Halassa MM, Ma WJ. A Low-Level Perceptual Correlate of Behavioral and Clinical Deficits in ADHD. Comput Psychiatr. 2018 Oct;2:141-163. doi: 10.1162/cpsy_a_00018. PMID: 30381800; PMCID: PMC6184361.

Krol A, Wimmer RD, Halassa MM, Feng G. Thalamic Reticular Dysfunction as a Circuit Endophenotype in Neurodevelopmental Disorders. Neuron. 2018 Apr 18;98(2):282-295. doi: 10.1016/j.neuron.2018.03.021. PMID: 29673480; PMCID: PMC6886707.

Halassa MM. Fronto-thalamic Architectures for Cognitive Algorithms. Neuron. 2018 Apr 18;98(2):237-239. doi: 10.1016/j.neuron.2018.04.006. PMID: 29673474.

Rikhye RV, Wimmer RD, Halassa MM. Toward an Integrative Theory of Thalamic Function. Annu Rev Neurosci. 2018 Jul 8;41:163-183. doi: 10.1146/annurev-neuro-080317-062144. Epub 2018 Apr 4. PMID: 29618284.

Halassa MM, Kastner S. Thalamic functions in distributed cognitive control. Nat Neurosci. 2017 Dec;20(12):1669-1679. doi: 10.1038/s41593-017-0020-1. Epub 2017 Nov 28. PMID: 29184210.

Busse L, Cardin JA, Chiappe ME, Halassa MM, McGinley MJ, Yamashita T, Saleem AB. Sensation during Active Behaviors. J Neurosci. 2017 Nov 8;37(45):10826-10834. doi: 10.1523/JNEUROSCI.1828-17.2017. PMID: 29118211; PMCID: PMC5678015.

Nakajima M, Halassa MM. Thalamic control of functional cortical connectivity. Curr Opin Neurobiol. 2017 Jun;44:127-131. doi: 10.1016/j.conb.2017.04.001. Epub 2017 May 6. PMID: 28486176; PMCID: PMC5604244.

Schmitt LI, Wimmer RD, Nakajima M, Happ M, Mofakham S, Halassa MM. Thalamic amplification of cortical connectivity sustains attentional control. Nature. 2017 May 11;545(7653):219-223. doi: 10.1038/nature22073. Epub 2017 May 3. PMID: 28467827; PMCID: PMC5570520.

Liang L, Oline SN, Kirk JC, Schmitt LI, Komorowski RW, Remondes M, Halassa MM. Scalable, Lightweight, Integrated and Quick-to-Assemble (SLIQ) Hyperdrives for Functional Circuit Dissection. Front Neural Circuits. 2017 Feb 13;11:8. doi: 10.3389/fncir.2017.00008. PMID: 28243194; PMCID: PMC5303737.

Foley J, Blutstein T, Lee S, Erneux C, Halassa MM, Haydon P. Astrocytic IP3/Ca2+ Signaling Modulates Theta Rhythm and REM Sleep. Front Neural Circuits. 2017 Jan 23;11:3. doi: 10.3389/fncir.2017.00003. PMID: 28167901; PMCID: PMC5253379.

Schmitt LI, Halassa MM. Interrogating the mouse thalamus to correct human neurodevelopmental disorders. Mol Psychiatry. 2017 Feb;22(2):183-191. doi: 10.1038/mp.2016.183. Epub 2016 Oct 11. PMID: 27725660; PMCID: PMC5258688.

Halassa MM, Acsády L. Thalamic Inhibition: Diverse Sources, Diverse Scales. Trends Neurosci. 2016 Oct;39(10):680-693. doi: 10.1016/j.tins.2016.08.001. Epub 2016 Aug 30. PMID: 27589879; PMCID: PMC5048590.

Wells MF, Wimmer RD, Schmitt LI, Feng G, Halassa MM. Thalamic reticular impairment underlies attention deficit in Ptchd1(Y/-) mice. Nature. 2016 Apr 7;532(7597):58-63. doi: 10.1038/nature17427. Epub 2016 Mar 23. PMID: 27007844; PMCID: PMC4875756.

Chen Z, Wimmer RD, Wilson MA, Halassa MM. Thalamic Circuit Mechanisms Link Sensory Processing in Sleep and Attention. Front Neural Circuits. 2016 Jan 5;9:83. doi: 10.3389/fncir.2015.00083. PMID: 26778969; PMCID: PMC4700269.

Wimmer RD, Schmitt LI, Davidson TJ, Nakajima M, Deisseroth K, Halassa MM. Thalamic control of sensory selection in divided attention. Nature. 2015 Oct 29;526(7575):705-9. doi: 10.1038/nature15398. Epub 2015 Oct 21. PMID: 26503050; PMCID: PMC4626291.

Lewis LD, Voigts J, Flores FJ, Schmitt LI, Wilson MA, Halassa MM, Brown EN. Thalamic reticular nucleus induces fast and local modulation of arousal state. Elife. 2015 Oct 13;4:e08760. doi: 10.7554/eLife.08760. PMID: 26460547; PMCID: PMC4686423.

Cohen SM, Halassa MM. Response to: NMDA hypofunction attenuates driver inputs in higher order thalamic nuclei: An alternative view. Schizophr Res. 2015 Aug;166(1-3):343-4. doi: 10.1016/j.schres.2015.04.020. Epub 2015 May 5. PMID: 25956632.

Cohen SM, Tsien RW, Goff DC, Halassa MM. The impact of NMDA receptor hypofunction on GABAergic neurons in the pathophysiology of schizophrenia. Schizophr Res. 2015 Sep;167(1-3):98-107. doi: 10.1016/j.schres.2014.12.026. Epub 2015 Jan 9. PMID: 25583246; PMCID: PMC4724170.

Brunetti PM, Wimmer RD, Liang L, Siegle JH, Voigts J, Wilson M, Halassa MM. Design and fabrication of ultralight weight, adjustable multi-electrode probes for electrophysiological recordings in mice. J Vis Exp. 2014 Sep 8;(91):e51675. doi: 10.3791/51675. PMID: 25225749; PMCID: PMC4309135.

Halassa MM, Chen Z, Wimmer RD, Brunetti PM, Zhao S, Zikopoulos B, Wang F, Brown EN, Wilson MA. State-dependent architecture of thalamic reticular subnetworks. Cell. 2014 Aug 14;158(4):808-821. doi: 10.1016/j.cell.2014.06.025. PMID: 25126786; PMCID: PMC4205482.


Enhancement of mediodorsal thalamus rescues aberrant belief dynamics in a mouse model with schizophrenia-associated mutation. Tingting Zhou, Yi-Yun Ho, Ray X. Lee, Amanda B. Fath, Kathleen He, Jonathan Scott, Navdeep Bajwa, Nolan D. Hartley, Jonathan Wilde, Xian Gao, Cui Li, Evan Hong, Matthew R. Nassar, Ralf D. Wimmer, Tarjinder Singh, Michael M. Halassa, Guoping Feng.  bioRxiv 2024.01.08.574745;

Spiking recurrent neural networks represent task-relevant neural sequences in rule-dependent computation. Xiaohe Xue, Michael M. Halassa, Zhe S. Chen bioRxiv 2021.01.21.427464;

Circuit Mechanisms of Top-Down Attentional Control in a Thalamic Reticular Model. Qinglong L. Gu, Norman H. Lam, Michael M. Halassa, John D. Murray bioRxiv 2020.09.16.300749;


Tufts University School of Medicine
Neuroscience Department
136 Harrison Ave., Boston, MA 02111


Tufts is committed to making physical and online resources available to everyone.

You Are Welcome Here

Halassa Lab is committed to creating a diverse environment. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.